294-2624, off I-19 at exit 92. Free. 7 a.m.–5 p.m. Allow 2–3 hours.
Established by Father Kino in 1732 and listed in the National Register of Historic Places. The Anza expedition stopped on October 25, 1775 to mourn the only death on the expedition and to celebrate three marriages. The mission is noted for its beautiful Spanish colonial architecture and colorful art adorning the interior.